GHK-Cu: The Copper Peptide Rewriting the Science of Skin & Longevity

GHK-Cu (Glycyl-L-Histidyl-L-Lysine : copper(2+)) is a copper-binding tripeptide that was first isolated from human plasma in the 1970s. Decades of research have revealed an astonishing breadth of biological activity.

Gene Expression Effects

One of GHK-Cu's most remarkable properties is its ability to influence gene expression. Research by Dr. Loren Pickart and colleagues found GHK-Cu modulates over 4,000 human genes — resetting many to a more youthful pattern of expression. Genes associated with inflammation, oxidative stress, and cancer progression were downregulated, while genes related to tissue repair and immune function were upregulated.

Skin and Collagen

GHK-Cu's most well-documented applications relate to dermal repair:

• ·Stimulates collagen, elastin, and glycosaminoglycan synthesis
• ·Activates collagenase to remove damaged collagen
• ·Promotes dermal fibroblast proliferation
• ·Reduces UV-induced skin damage
• ·Improves wound contraction and re-epithelialization

Antioxidant Properties

GHK-Cu exhibits potent antioxidant activity by:

• ·Chelating free copper ions that catalyze oxidative reactions
• ·Inducing antioxidant enzymes including superoxide dismutase
• ·Reducing inflammation through NF-κB pathway modulation

Systemic Effects

Beyond skin, research has explored GHK-Cu's role in:

• ·Lung tissue protection and COPD-related pathways
• ·Nerve regeneration
• ·Hair growth stimulation
• ·Bone density maintenance

Application Routes in Research

GHK-Cu has been studied via topical application (cream/serum formulations) as well as subcutaneous injection. Topical concentrations range widely in cosmetic research. Injectable research typically uses very small doses given the peptide's high potency.

Note: GHK-Cu is sold strictly for research purposes. Not for human use.