Research & Science
The JA Performance Blog
In-depth guides, research breakdowns, and protocol resources for the peptide research community.
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AICAR vs SLU-PP-332: Exercise Mimetic Peptide Research Compared
AICAR and SLU-PP-332 are both studied as exercise mimetics — compounds that trigger metabolic adaptations normally associated with physical training. Here's how their mechanisms differ.
Thymosin Alpha-1: Immune System Modulation Peptide Research
Thymosin Alpha-1 is a naturally occurring thymic peptide studied extensively for its role in immune regulation. Here's what decades of research reveal about its mechanisms and applications.
SS-31 (Elamipretide): Mitochondrial-Targeted Peptide Research
SS-31 is a mitochondria-penetrating peptide studied for its ability to stabilize cardiolipin and protect the electron transport chain. Here's how it differs from other longevity-focused research peptides.
Kisspeptin-10: The Reproductive Hormone Axis Peptide
Kisspeptin-10 sits at the top of the hypothalamic-pituitary-gonadal axis, controlling the release of GnRH. Here's what research shows about its role in reproductive endocrinology.
Cerebrolysin: Neuropeptide Research for Cognitive Function
Cerebrolysin is a complex mixture of neurotrophic peptide fragments derived from porcine brain protein, studied extensively for neuroprotection and cognitive research. Here's what the evidence shows.
Semaglutide for Weight Loss Research: How the GLP-1 Peptide Works
Semaglutide is the GLP-1 receptor agonist behind the modern obesity research boom. Here's how it modulates appetite, what the trial data shows, and how researchers handle it.
PT-141 (Bremelanotide): The Research Peptide for Sexual Function
PT-141 works through the central nervous system rather than the vascular route of most libido compounds. Here's the melanocortin science, the research data, and how it's handled.
Semax and Selank: The Nootropic Peptides Explained
Semax and Selank came out of Russian neuroscience research and target cognition and anxiety through different pathways. Here's how each works and how researchers use them.
5-Amino-1MQ: The NNMT Inhibitor in Fat Loss and Longevity Research
5-Amino-1MQ is a small molecule that blocks the NNMT enzyme to raise cellular NAD+ and shrink fat cells in research models. Here's the mechanism and what studies show.
Cagrilintide: The Amylin Analogue Advancing Obesity Research
Cagrilintide targets the amylin system — a satiety pathway separate from GLP-1 — and is studied both alone and stacked with semaglutide. Here's the science.
How to Inject Peptides Subcutaneously: A Research Handling Guide
Subcutaneous injection is the most common route in peptide research. This step-by-step guide covers technique, needle selection, sites, and sterile handling.
Epithalon: Telomere Science and the Most Studied Anti-Aging Peptide
Epithalon is a tetrapeptide derived from the pineal gland with documented telomerase activation and telomere lengthening in human somatic cells. Here's what decades of research show.
BPC-157 and Gut Health: Research Into the Gastric Protection Compound
BPC-157 was originally isolated from gastric juice — and gut health remains its most documented application in preclinical research. Here's what the evidence shows for ulcers, IBD, and gut-brain research.
The Wolverine Stack: BPC-157 + TB-500 Combined Research Protocol
The Wolverine Stack pairs BPC-157 and TB-500 into a single combined healing research protocol. Here's the mechanistic rationale, how the two compounds interact, and how researchers structure the protocol.
Where to Buy Peptides in Canada: The 2026 Guide
A complete guide to sourcing research-grade peptides in Canada — what to look for, red flags to avoid, and why third-party testing is the only standard that matters.
Best Research Peptide Suppliers in Canada (2026)
A research-focused breakdown of what separates legitimate Canadian peptide suppliers from grey-market vendors — covering testing standards, documentation, shipping, and red flags.
Ipamorelin: The Selective Growth Hormone Secretagogue Explained
Ipamorelin is the cleanest GHRP available for research — selective GH release without the cortisol, prolactin, or appetite side effects of older compounds. Here's a complete research guide.
Fat Loss Peptide Stacks: Retatrutide + Tesamorelin Research Protocol
Retatrutide and Tesamorelin target fat loss through entirely different mechanisms — one drives systemic caloric reduction, the other targets visceral fat through growth hormone. Here's how researchers are combining them.
Best Peptides for Tendon and Ligament Repair: What the Research Shows
Tendon injuries are notoriously slow to heal due to poor vascularization. Several peptides have emerged as leading candidates in preclinical research for accelerating tendon-to-bone and ligament repair.
Peptide Cycling: When to Run, Rest, and Stack in Research Protocols
Continuous peptide administration is not always optimal — receptor desensitization, feedback suppression, and diminishing returns are all well-documented. Here's how researchers approach cycling strategies.
Ipamorelin & CJC-1295: The Research Behind Growth Hormone Peptides
Ipamorelin and CJC-1295 are two of the most studied growth hormone secretagogues. Learn how they work, how they differ, and why researchers often stack them.
MOTS-c vs GHK-Cu: Two Different Approaches to Longevity Research
MOTS-c and GHK-Cu are both studied for anti-aging effects, but they operate through entirely different biology — one from mitochondrial DNA, one from plasma copper chemistry. Here's how researchers compare them.
BPC-157 vs TB-500: Which Peptide Is Right for Your Research Protocol?
BPC-157 and TB-500 are the two most popular healing peptides — but they work differently. Here's a detailed comparison of mechanisms, applications, and why many researchers use both.
Peptide Storage Guide: Temperature, Light, and Shelf Life Explained
Improper storage is the most common way researchers degrade their peptides before use. This guide covers lyophilized vs reconstituted storage, freeze-thaw cycles, and shelf life by compound.
Semaglutide vs Tirzepatide vs Retatrutide: Comparing GLP-1 Peptides
A research-focused comparison of the three leading GLP-1-based peptides — semaglutide, tirzepatide, and retatrutide — covering mechanisms, clinical data, and key differences.
BPC-157: The Complete Guide to Body Protection Compound
BPC-157 is one of the most researched peptides for tissue repair and healing. Here's what the science says about mechanisms, dosing, and protocols.
Tesamorelin: GHRH Analogue for Fat Loss and Growth Hormone Research
Tesamorelin is an FDA-approved GHRH analogue with a compelling research profile for visceral fat reduction and growth hormone axis modulation. Here's what the science shows.
TB-500: Accelerating Recovery with Thymosin Beta-4
TB-500 is a synthetic fragment of thymosin beta-4 with potent anti-inflammatory and regenerative effects. Learn how researchers are applying it for soft tissue repair.
MOTS-c: The Mitochondrial Peptide at the Frontier of Longevity Research
MOTS-c is a peptide encoded in mitochondrial DNA — not nuclear DNA — making it unique among all known peptides. Research links it to metabolic regulation, exercise mimicry, and healthy ageing.
NAD+ Precursors and Peptides: What Longevity Research Actually Shows
NAD+ decline is one of the most studied hallmarks of aging. Here's how peptides and NAD+ precursors are being researched together to address cellular energy, DNA repair, and lifespan extension.
GHK-Cu: The Copper Peptide Rewriting the Science of Skin & Longevity
GHK-Cu is a naturally occurring copper-binding tripeptide with an extraordinary range of biological effects — from collagen synthesis to gene expression remodelling.
How to Use a Peptide Dosing Calculator (And Do the Math Yourself)
Converting between mg, mcg, IU, and mL trips up many researchers. This guide explains peptide dosing math step by step — and shows you how to use JA Performance's free dosing calculator.
How to Read a Certificate of Analysis (COA) for Research Peptides
A COA is the most important document for verifying peptide quality and purity. Here's exactly what to look for — and the red flags that indicate a product isn't research-grade.
How to Reconstitute Peptides: A Step-by-Step Research Guide
Proper reconstitution is critical for peptide research. This guide covers bacteriostatic water, dilution math, sterile technique, and storage best practices.
Retatrutide: The Triple Agonist Changing Weight Loss Research
Retatrutide simultaneously targets GIP, GLP-1, and glucagon receptors, making it the most potent metabolic peptide studied to date. Here's what the clinical data shows.