Semax and Selank: The Nootropic Peptides Explained
Semax and Selank came out of Russian neuroscience research and target cognition and anxiety through different pathways. Here's how each works and how researchers use them.
Semax and Selank are the two best-known nootropic peptides, both developed in Russia and used there clinically for decades. They are frequently studied together because their mechanisms are complementary: one is oriented toward cognition and neuroprotection, the other toward anxiety and stress regulation.
What Is Semax?
Semax is a synthetic peptide derived from a fragment of ACTH (adrenocorticotropic hormone), modified for stability. It was developed at the Institute of Molecular Genetics in Moscow and has been used in neurological research and clinical settings, including stroke recovery protocols.
How Does Semax Work?
- ·BDNF upregulation — increases brain-derived neurotrophic factor, supporting synaptic plasticity and neuronal survival
- ·Neuroprotection — studied for protecting neural tissue against ischemic and oxidative stress
- ·Dopaminergic and serotonergic modulation — influences neurotransmitter systems tied to focus and mood
- ·Cognitive endpoints — research has examined attention, memory, and mental fatigue
What Is Selank?
Selank is a synthetic analogue of tuftsin, an immune-modulating peptide fragment. It was developed as an anxiolytic (anti-anxiety) research peptide without the sedation or dependence associated with benzodiazepines.
How Does Selank Work?
- ·GABAergic modulation — influences the GABA system associated with calm and reduced anxiety
- ·Enkephalin regulation — slows the breakdown of enkephalins, extending their calming and analgesic signalling
- ·Immune modulation — the tuftsin lineage gives it activity on immune signalling
- ·Anti-anxiety endpoints — studied for stress response without sedation
Semax vs Selank: Which for What?
They are often paired precisely because they address different endpoints:
- ·Semax — cognition, focus, neuroprotection, mental fatigue
- ·Selank — anxiety, stress regulation, calm without sedation
A researcher studying the interplay of cognition and stress may examine them together, though each is also studied alone. Both are commonly administered as subcutaneous injections or intranasally in research settings.
Reconstitution and Handling
Both peptides are supplied as lyophilized powder and reconstituted with bacteriostatic water. Store frozen or refrigerated and protect from light. See our reconstitution guide and storage guide.
Available at JA Performance
Both are stocked at ≥99% purity, verified by independent third-party laboratory testing:
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Note: Semax and Selank are sold strictly for laboratory and in vitro research purposes. Not for human consumption.