MK-677 / Ibutamoren (Oral)
Dosing protocol
Quick Reference
Overview
MK-677 (Ibutamoren) is an orally active, non-peptide ghrelin mimetic and growth hormone secretagogue receptor (GHSR) agonist. By mimicking ghrelin, it stimulates pulsatile GH release from the pituitary and elevates circulating IGF-1 without suppressing the hypothalamic-pituitary axis. Research applications include GH-deficiency models, muscle preservation studies, sleep architecture research, and bone mineral density investigations. The oral bioavailability of MK-677 is high (~60–70%), and its half-life of 4–6 hours supports once-daily dosing.
Dosing & Reconstitution Guide
| Phase | Daily Dose | Units | Volume |
|---|---|---|---|
| Weeks 1–2 | 10 mg/day | Per label | N/A |
| Weeks 3–8 | 15–20 mg/day | Per label | N/A |
| Weeks 9–16 (optional) | 25 mg/day | Per label | N/A |
Reconstitution Instructions
MK-677 is supplied as an oral solution or capsule — no reconstitution is required.
Measure or count the specified dose using the provided dropper or capsule count.
Administer orally with or without food; taking with food may reduce nausea from ghrelin stimulation.
Store the formulation in a cool, dry location away from direct light.
This guide is for educational purposes only and is not medical advice. For research use only. Not for human consumption.
Supplies Needed
- ✓MK-677 (Ibutamoren) — oral solution or capsules: 8-week supply
- ✓Oral dosing syringe (if liquid formulation): 1
Dosing Protocol
Schedule
Administer once daily, preferably at bedtime. Nighttime dosing aligns with the natural pulsatile release of GH during slow-wave sleep, potentially enhancing the secretagogue effect.
Cycle Length
8–16 weeks. Longer cycles of 3–6 months have been used in GH-deficiency research under controlled conditions. A 4–8 week off period allows GHSR sensitivity to normalise.
Appetite
Significant appetite stimulation is expected due to ghrelin receptor activation — a well-documented and expected pharmacological effect in research models.
Storage & Handling
- ✓Store at room temperature (15–25 °C) in a dry location away from heat and direct light.
- ✓If liquid formulation: refrigerate after opening and use within 60 days; shake well before each dose.
- ✓Keep container tightly sealed between uses to prevent moisture ingress.
- ✓Discard capsules or liquid that shows signs of degradation (colour change, precipitation, off-odour).
Important Notes
- ✓All products sold by JA Performance Peptides are intended strictly for laboratory research purposes and are not approved for human consumption, veterinary use, or therapeutic application. Not for human use.
- ✓MK-677 is not a steroid or SARM; however, it is not approved for human therapeutic use in most jurisdictions.
- ✓GH-stimulating compounds can transiently increase fasting glucose and insulin resistance — relevant for metabolic research designs.
- ✓Increased water retention is a common early-phase effect in research models.
- ✓Water retention and appetite effects typically diminish after 2–4 weeks of consistent dosing.
- ✓Document bodyweight, sleep quality, and appetite observations as relevant research endpoints.